【干冰】Anti-eIF3S6/Int6 (RABBIT) Antibody - 600-401-A62S-【干冰】Anti-eIF3S6/Int6 (RABBIT) Antibody - 600-401-A62S代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: 【干冰】Anti-eIF3S6/Int6 (RABBIT) Antibody - 600-401-A62S

英文名字: 【干冰】Anti-eIF3S6/Int6 (RABBIT) Antibody - 600-401-A62S

供应商: Rockland

产品货号: 600-401-A62S

产品报价: ￥询价/25uL

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背景资料: This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI). Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex. There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stress-responsive genes. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth. Anti-eIF3S6/Int6 Antibody is useful for researchers interested in cancer and apoptosis research.

应用类型: ELISA,Western Blot,

免疫原: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminus of mouse EIF3S6/Int6.

来源宿主: Rabbit

反应性: H. sapiens (Human); Mus musculus (Mouse); Simiiformes (Monkey)

保存建议: Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 µL). To minimize loss of volume dilute 1:10 by adding 225 µL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.

其他: Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。