SIRT7抗体-SIRT7 Antibody （SIR2； Sirtuin 7； Silent Information Regulator 7）代理/参数/厂家-二抗-开云·官方站线上登录平台入口

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二抗

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背景资料: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases （class III HDACs） and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. SIRT7 is a member of this family of proteins and is present in prokaryotes and eukaryotes. All SIR2-like proteins have a sirtuin core domain，which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial，yeast，and mammalian sirtuins are able to metabolize NAD+ and several act as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but as mentioned above，recent reports of histone-activated SIR2-mediated NAD+ metabolism and NAD+-activated SIR2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of SIR2 with NAD+ and the N-ε-acetyl-lysine groups of acetylated histone.

应用类型: Western blot: 1-3 ug/ml. However， the optimal conditions should be determined individually.

保存建议: 提供的SIRT7抗体产品为无色溶液形式，含有50 ug抗体.该产品浓度为与批次相关，溶解于包含有0.2% gelatin和0.05%叠氮化钠的PBS缓冲液中.请在收到该SIRT7抗体产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

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