FKBP1A is part of the family of immunophilins, which have in common high affinity for immunosuppressant drugs and a peptidyl-prolyl cis-trans isomerase (PPIase). In the absence of immunosuppressive ligands, FKBP1A is involved in intracellular calcium regulation by associating with 3 types of Ca2+ release channel complexes: skeletal ryanodine receptors, cardiac ryanodine receptors and the inositol 1, 4, 5-triphosphate receptor. FKBP1A also interacts with TGF type I receptor exerting an inhibitory effect on the TGFβ-I signaling pathway. FKBP12 plays a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. FKBP1A increase the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
序列
重组人FKBP1a/FKBP12蛋白产品,又称FK506 binding protein 1a, 12kDa, PPIase FKBP1A, Rotamase, FKBP1, PKC12.其对应NCBI基因号为2280,对应Accession号为P62942.
来源宿主
提供的【FKBP1a】重组人FKBP1a/FKBP12产品的来源为大肠杆菌重组表达.
溶解建议
重组人FKBP1a/FKBP12产品为液体即用型,其溶液组成为:1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 1 mM DTT and 10% glycerol.