Ubc13 is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Ubc13 acts with the UEV protein Mms2 forming a heterodimeric complex that assembles K63-linked polyubiquitin chains utilized in nondegradative ubiquitin signaling pathways (DNA repair, signal transduction). The Ubc13/Mms2 complex is unique in that it has the ability to form free K63-linked polyubiquitin chains in solution in the absence of an E3. UBE2N mediates the transcription of some target genes and is believed to have a role in cell cycle progression; cellular differentiation and DNA repair mechanisms which ensure cell survival after DNA damage.
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重组酵母Ubc13 (泛素蛋白连接酶UBE2N)蛋白产品,又称Ubiquitin-conjugating enzyme E2 N, Bendless-like ubiquitin-conjugating enzyme, Ubiquitin carrier protein N, Ubiquitin-protein ligase N, BLU, MGC8489, UbcH-ben, MGC131857.其对应NCBI基因号为851666,对应Accession号为P52490.