Ubiquitin-conjugating enzyme E2 (UBE2E2) is a protein that in humans is encoded by the UBE2E2 gene. Amino acid sequence within the UBC domain of UBE2E2 shares over 90% identity with human UbcH6, mouse UbcM2, and Drosophila UbcD2, whereas the N-terminal region shows little amino acid sequence similarity with known proteins. The UBE2E2 protein forms a thioester bond with ubiquitin in an E1-dependent manner and mediates the transfer of ubiquitin from a ubiquitin-activating enzyme (E1) to a substrate protein or E3 ligase.
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重组人泛素蛋白连接酶UBE2E2 (泛素偶联酶UbcH8)蛋白产品,又称RIG-B, UBCH8, MGC40331, UBE2L6, Ubiquitin/ISG15-conjugating enzyme E2 L6, Ubiquitin-protein ligase L6, Ubiquitin carrier protein L6, and Retinoic acid-induced gene B protein.其对应NCBI基因号为7325,对应Accession号为Q96LR5.