Caspase-10 Antibody [FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE like Apoptotic Protease 4 ]
供应商
Biovision
产品货号
6677-100
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背景资料
Caspase family of cysteine proteases plays a key role in apoptosis. Caspase-10 is expressed in many tissues and cell lines. Similar to other caspases,caspase-10 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Four isoforms of caspase-10 have been identified: caspase-10a (Mch4),caspase-10b (FLICE2),caspase-10c and caspase-10d. They have the same prodomain but different mature large and small subdomains. Activated caspase-10 activates caspase-3,-4,-6,-7,-8,and –9,which are then involved in proteolytic cleavage of many cellular proteins. Caspase-10 has been shown to be involved in the Fas and TNFR1 - induced apoptosis.