ALDH5A1 Antibody (ALDH5A1; SSADH; Succinate-semialdehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase family 5 members A1; NAD (+)-dependent succinic semialdehyde dehydroge
供应商
Biovision
产品货号
6750-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde,as well as in lipid peroxidation and in the metabolism of corticosteroids,biogenic amines and neurotransmitters. ALDH5A1 (aldehyde dehydrogenase 5 family,member A1),also known as SSDH or SSADH,is a 535 amino acid protein that localizes to the mitochondria and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues,including liver,heart,lung,brain,kidney and placenta,ALDH5A1 is required for gamma-aminobutyric acid (GABA) recycling from the synaptic cleft. Mutations of ALDH5A1 lead to succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) that is characterized by severe ataxia and by mildly retarded psychomotor development.
应用类型
Western blot: ~1:1000, IHC: ~1:50-1:100, FACS: ~1:10-1:50.
免疫原
This ALDH5A1 antibody is generated from rabbits immunized with human ALDH5A1 recombinant protein.