ETO polyclonal antibody (RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2)
供应商
Biovision
产品货号
6834-50
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t (8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. This translocation produces a chimeric gene made up of the 5’-region of AML1 and the 3’-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
应用类型
ChIP: 4 ul/ChIP, ELISA: 1:100.
免疫原
Polyclonal antibody against human ETO using two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively.