Human CellExp™ HER3 / ErbB3 Extracellular Domain (ED), Human Recombinant
供应商
Biovision
产品货号
7400-250
产品报价
¥已停产
产品说明书
购买方式
银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868.
产品新闻
背景资料
ErbB3, also called human epidermal growth factor receptor 3 (HER3), is a type I membrane glycoprotein and a member of the ErbB family. ErbB family members serve as receptors for the epidermal growth factors (EGF). ErbB3 is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. ErbB3 is the only member with a defective kinase domain among ErbB family members. However, ErbB3 can form heterodimers with ErbB2 to complement a high affinity receptor complex. ErbB3 has been shown to bind the ligands heregulin and NRG-2. The lethal congenital contracture syndrome 2 (LCCS2) disease is caused by mutations affecting ErbB3. ErbB3 null mouse embryos show severely underdeveloped atrioventricular valves, leading to death at embryonic day 13.5.