中文名称

【GRK5】GRK5蛋白，有活性的（5微克）

英文名字

GRK5, Active

供应商

Biovision

产品货号

7709-5

产品报价

￥已停产

产品说明书

购买方式

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产品新闻

背景资料

G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Haribabu and Snyderman (1) identified GRK5 and GRK6. GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Bullrich (2) used a rodent-human hybrid panel to map 2 newly identified members of the GRK family: GPRK5 and GPRK6 to 10q24-qter and 5q35, respectively. Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop upon contact with pathogens or target cells, and this desensitization is mediated by GRKs (3). MIP2 induces GRK2 and GRK5 expression in PMNs through PI3KG signaling. However, lipopolysaccharide (LPS), acting through TLR4 signaling, mediated through MEK1 /MEK2, transcriptionally downregulates expression of GRK2 and GRK5 in response to MIP2, which decreases chemokine receptor desensitization and markedly augments PMN migration. Thus, LPS-activated TLR4 signaling regulates PMN migration by modulating the expression of chemokine receptors in a GRK2- and GRK5-dependent manner.

序列

GRK5蛋白,有活性的蛋白产品，又称GRK, G protein-coupled receptor kinase 5 .其对应NCBI基因号为5753，NCBI基因别称为PTK6源，对应Accession号为NM_005975.该蛋白产品又称grk-5, grk 5, Active GRK5, GRK5, human GRK5, active kinase, active kinases, GRK, recombinant GRK5, recombinant GRK, kinase activity assay, protein kinase等.

来源宿主

提供的【GRK5】GRK5蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.

溶解建议

提供的GRK5蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.

保存建议

在您收到艾美捷发出的【GRK5】GRK5蛋白,有活性的产品后，建议将其置于-80°C保存.

其他

BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的Leader，BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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