Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. Protein kinase C epsilon (PRKCE), one of the PKC family members, has been shown to be involved in many different cellular functions, such as neuron channel activation (1), apoptosis (2), cardioprotection from ischemia (3, 4), heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior (5).
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PKCepsilon蛋白,有活性的蛋白产品,又称PKC, protein kinase C, epsilon.其对应NCBI基因号为7535,NCBI基因别称为ZAP70源,对应Accession号为P43403.该蛋白产品又称Active PKCepsilon, PKCepsilon, PKC, human PKCepsilon, active kinase, active kinases, recombinant PKCepsilon, recombinant PKC, kinase activity assay, protein kinase 等.