Mitogen-activated protein kinase (MAPK) cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses, and involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The stress-activated protein kinase 4 (SAPK4), or p38 delta, is a member of the MAPK family that are activated by chemical and environmental stresses as well as by proinflammatory cytokines. SAPK4 has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines (1). MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase (2).
序列
P38delta蛋白,有活性的蛋白产品,又称p38, mitogen-activated protein kinase 13.其对应NCBI基因号为5581,NCBI基因别称为PRKCE源,对应Accession号为Q02156.该蛋白产品又称Active P38delta, P38delta, P38, p38, p38delta, p38d, human P38delta, active kinase, active kinases, recombinant P38delta, recombinant P38d, kinase activity assay, protein kinase等.
来源宿主
提供的【P38δ】P38delta蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
溶解建议
提供的P38delta蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.