p38a (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response (5).
序列
p38α蛋白,有活性的蛋白产品,又称p38, mitogen-activated protein kinase 14.其对应NCBI基因号为7867,NCBI基因别称为MAPKAPK3源,对应Accession号为Q16644.该蛋白产品又称Active p38alpha, p38alpha, p38, p38 alpha, p38a, human P38alpha, active kinase, active kinases, recombinant P38a, recombinant P38, kinase activity assay, protein kinase等.
来源宿主
提供的【p38a】p38α蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
溶解建议
提供的p38alpha蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.