JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.
序列
JNK1蛋白,有活性的蛋白产品,又称JNK, mitogen-activated protein kinase 8, MAP kinase p49 3F12, Stress-activated protein kinase 1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3.其对应NCBI基因号为5599,NCBI基因别称为JNK1源,对应Accession号为 P45983.该蛋白产品又称JNK-1, JNK 1, Active JNK1, JNK1, JNK, human JNK1, active kinase, active kinases, recombinant JNK1, recombinant JNK, kinase activity assay, protein kinase等.
来源宿主
提供的【JNK1】JNK1蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
溶解建议
提供的JNK1蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.