TRKB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TRKB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations (1). TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway (2). Signalling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and mood disorders.
序列
TrkB蛋白,有活性的蛋白产品,又称TrkB, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B.其对应NCBI基因号为5599,NCBI基因别称为JNK1源,对应Accession号为 P45983.该蛋白产品又称Active TrkB, TrkB, Trk, human TrkB, active kinase, active kinases, recombinant TrkB, recombinant Trk, kinase activity assay, protein kinase等.
来源宿主
提供的【TrkB】TrkB蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
溶解建议
提供的TrkB蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.