HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. HER2 is an oncogene and overexpression of unaltered HER2 coding sequences in NIH 3T3 cells results in cellular transformation and tumorigenesis (1). HER2 is amplified in about 30% of primary human breast malignancies and overexpression of HER2 is associated with the most aggressive tumors that show uncontrolled proliferation, resistance to apoptosis and increased motility (2).
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HER2蛋白,有活性的蛋白产品,又称HER, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3.其对应NCBI基因号为4921,NCBI基因别称为DDR2源,对应Accession号为NM_006182.该蛋白产品又称HER-2, HER 2, Active HER2, HER2, HER, human HER2, active kinase, active kinases, recombinant HER2, recombinant HER, kinase activity assay, protein kinase 等.
来源宿主
提供的【HER2】HER2蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
溶解建议
提供的HER2蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.