RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2).
序列
RSK2蛋白,有活性的蛋白产品,又称RSK, ribosomal protein S6 kinase, 90kDa, polypeptide 3, MAP kinase-activated protein kinase 1c.其对应NCBI基因号为2444,NCBI基因别称为FRK源,对应Accession号为NM_002031.该蛋白产品又称RSK-2, RSK 2, Active RSK2, RSK2, RSK, human RSK, active kinase, active kinases, recombinant RSK2, recombinant RSK, kinase activity assay, protein kinase等.
来源宿主
提供的【RSK2】RSK2蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
溶解建议
提供的RSK2蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.