PDGFRb (platelet-derived growth factor receptor b) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRb deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function (1). However, absence of PDGFRb has no impact on major blood vessels and the heart. PDGFRb expression and activity is elevated in several cancers and inhibition of PDGFRb activity blocks progression of renal carcinoma in an animal model (2).
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血小板衍生因子受体 β蛋白,有活性的蛋白产品,又称PDGR. platelet-derived growth factor receptor, beta polypeptide.其对应NCBI基因号为6197,NCBI基因别称为RPS6KA3源,对应Accession号为NM_004586.该蛋白产品又称Active PDGFR beta, PDGFR beta, PDGFR, human PDGFR beta, active kinase, active kinases, recombinant PDGFR beta, recombinant PDGFR, kinase activity assay, protein kinase等.