Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody
供应商
Biovision
产品货号
A1092-200
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
The antibody binds specifically to a5ß1 integrin,which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin,vitronectin,laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation,cell proliferation,angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody,a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV),in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.