Pregnancy-associated plasma protein A (PAPP-A) is a large placenta-derived glycoprotein. During pregnancy it is produced in high concentrations by the trophoblast and released into maternal circulation. In addition to trophoblasts, PAPP-A expression has been reported in various tissues, including endometrium, testis, kidney, bone, colon, and other adult and fetal tissues. PAPP-A is potentially proatherosclerotic and has been proposed as a new marker of inflammation, as high serum PAPP-A levels are observed in patients with renal impairment, asthma, lung cancer, etc. Studies suggest that the PAPP-A form in non-pregnant females and males is dimeric and is not complexed with proMBP.
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产品描述
The picoPAPP-A enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of PAPP-A in human serum and other biological fluids.