CaV2.2抗体（25 ul）-Anti-CaV2.2代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: Voltage dependent Ca2+ channels (CaV channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.The voltage dependent Ca2+ channels are composed of several subunits; α1, β, α2δ and γ. CaV channels were originally divided into six physiological types: L, N, P, Q, R, and T type.The CaV2.2 (formally named α1B) composes the α1 poreforming subunit for the N type Ca2+ channel family. They are involved in neurotransmitter release from central neurons, including glutamate, γ-aminobutyric acid, acetylcholine, dopamine and noradrenaline.The CaV2.2 is expressed preferentially in the central nervous system, where along with CaV2.1, it is responsible for pre-synaptic Ca2+ influx and neurotransmitter release.The CaV2.2 channel is negatively regulated by many different GPCRs. There are two ways that this is done: either by directly binding Gβγ to the channel or by an indirect mechanism involving second messenger and channel phosphorylation.

免疫原: CaV2.2 抗体的免疫原肽段为(C)RHHRHRDRDKTSASTPA。此免疫原序列来源于851-867 位氨基酸残基，该序列来源于大鼠Cav2。2 (Accession编号为Q02294)。胞内环位于结构域 II和III。

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