CaV2.3抗体（50 ul）-Anti-CaV2.3代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: Voltage-dependent Ca2+ channels (Cav channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.The voltage dependent Ca2+ channels are composed of several subunits; α1, β, α2δ and γ. Cav channels were originally divided into six physiological types: L, N , P, Q, R, and T type.The Cav2.3 (formerly named α1E) protein, forms the R type channels. R-type channels are highly sensitive to both SNX-482 (#RTS-500) and NiCl2. Cav2.3 channels were shown to mediate fast excitatory transmission in several synapses including the hippocampus.Cav2.3 channels can be modulated by the muscarinic G-protein coupled receptors. nIn HEK-293 cells, expressing Cav2.3 channels, the R-type channel was shown to be both facilitated and inhibited by m1 and m2 muscarinic receptors. However, inhibition was much weaker than facilitation for the m1 receptor, while for m2 receptors, inhibition was much more pronounced than activation.

免疫原: CaV2.3抗体的免疫原肽段为(C)SASQERSLDEGVSIDG。此免疫原序列来源于892-907 位氨基酸残基，该序列来源于大鼠CaV2。3 (Accession编号为Q07652)。胞内环位于结构域 II和III。

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