TRPA1（胞外）抗体（25 ul）-Anti-TRPA1 （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: The TRPA family is comprised of only one mammalian member, the TRPA1 (formerly named ANKTM1). TRPA1 is expressed in peripheral sensory neurons, where it is suggested to contribute to the detection of painful stimuli.nOriginally it was thought that TRPA channels sensed painfully cold temperatures, but a more conservative description is that TRPA1 is sensitive to membrane/cytoskeletal perturbations by cold and perhaps stretch.6 In addition, it is sensitive to pungent natural compounds present in cinnamon oil, mustard oil, and wintergreen oil.nTRPA1 is also expressed in hair cells, where its role in sensing mechanical forces is still unclear and controversial.nTRPA1 has similar structure as all TRP ion channel members, six transmembrane domains, intracellular N-and C-terminus. However, its N-terminus domain possesses 17 ankyrin repeats that might indicate its potential role as a mechanosensor.TRPA1 is expressed in nociceptive neurons expressing TRPV1 as well and might serve as a marker for poly-modal nociceptors.

免疫原: TRPA1 (胞外)抗体的免疫原肽段为(C)NSTGIINETSDHSE。此免疫原序列来源于747-760位氨基酸残基，该序列来源于人类TRPA1 (Accession编号为O75762)，第二胞外环。

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