游离脂肪酸受体1（胞外）抗体（50 ul）-Anti-Free Fatty Acid Receptor 1 （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: 游离脂肪酸受体1（胞外）抗体（50 ul）

英文名字: Anti-Free Fatty Acid Receptor 1 （extracellular)

供应商: Alomone

产品货号: ALO-AFR-011-50

产品报价: ￥已停产

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产品新闻

背景资料: Free fatty acids (FFAs) were for long believed to influence cellular metabolism. Hoever, the discovery that FFAs actually mediate their effects through one of three G-protein coupled receptors (GPCRs) - Free Fatty Acid Receptors 1-3 (FFAR1-3), has initiated a number of studies in order to assess their implication in health and disease.nLike all other GPCRs, FFAR1-3 have seven transmembrane domains, an extracellular N-terminal tail and an intracellular C-terminus.nFFAR1 is activated by either medium or long, saturated or unsaturated fatty acids, whereas FFAR2 and FFAR3 are activated by short chain fatty acids. FFAR1 is coupled to Gq and leads to Ca2+ mobilization upon activation. FFAR2 couples to both pertussis-sensitive and insensitive G-proteins and also leads to increased intracellular Ca2+ levels. FFAR3 coupling to G-protein induces an increase in cAMP1.nDistribution studies of all three FFA Receptors indicate that FFAR1 mRNA is quite elevated in the pancreas. FFAR1 is also detected in the liver, heart, skeletal muscle, and brain; although this broad localization pattern is supported only by one study. FFAR2 is expressed in many tissues like liver and colon6. FFAR3 is expressed in many tissues but shows highest expression in adipose tissue4. Relatively high expression of the receptor could be detected in pancreas, spleen, lymph nodes and bone marrow.nAs mentioned above, the finding that FFAs’ actions are mediated by GPCRs, prompted many studies in order to elucidate their roles in healthy and disease states. Such studies stipulate that FFAR1 may be involved in obesity and type 2 diabetes since circulating free fatty acid levels in the plasma are significantly elevated. On the other hand, FFAR2 and FFAR3 could be potential targets for treating irritable bowel disease and appetite control.

应用类型: 经验证，该抗体可应用于WB

免疫原: Free Fatty Acid 受体 1 (胞外)抗体的免疫原肽段为肽段：, (C)NVASFINPDLEGSWRK 对应的氨基酸残基： 244-259 位氨基酸残基，该序列来源于大鼠free fatty acid 受体 1 (Accession编号为Q8K3T4)

来源宿主: 兔

反应性: 反应性：大鼠

保存建议: 艾美捷为您提供的Free Fatty Acid 受体 1 (胞外)抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。

其他: Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。