GABA（A）Alpha2受体抗体（50 ul）-Anti-GABA （A) Alpha2 Receptor代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.nThe GABA transmitter interacts with two major types of receptors: ionotropic GABAA (GABAAR) and the metabotropic GABAB receptors. The GABAAR belong to the ligand gated ion channel superfamily.nThe GABAAR, is a heteropentamer, with all of its five subunits contributing to the pore formation. To date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunit isoforms were described to exist in mammals (α1-α6). The native GABAA receptor, in most cases, consists of 2α, 2β and 1γ submit. The α subunit is the most common subunit and is expressed ubiquitously. It determines the affinities for allosteric ligands shown by GABAAR. nThe α2-subunit mRNA is strongly expressed only in the hippocampus and the hypothalamus. It occurs very early in rat brain development and declines in adulthood. nThe failure to complete the normal transition between the a-subunits that are highly expressed in early development (α2, α3, α5) to those expressed in adulthood (α1) might play a major role in the development of temporal lobe epilepsy.

免疫原: GABA (A) Alpha2 受体抗体的免疫原肽段为(C)TPEPNKKPENKPA。此免疫原序列来源于393-405 位氨基酸残基，该序列来源于大鼠GABA (A) α2 受体 (Accession编号为 P23576)。第二胞内环。

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