GABA（A）Beta1受体抗体（25 ul）-Anti-GABA（A) Beta1 Receptor代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: GABA（A）Beta1受体抗体（25 ul）

英文名字: Anti-GABA（A) Beta1 Receptor

供应商: Alomone

产品货号: ALO-AGA-010-25

产品报价: ￥已停产

产品说明书

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产品新闻

背景资料: γ-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the vertebrate central nervous system (CNS) mediates fast synaptic transmission via ionotropic GABA(A) receptors. These receptors are pentameric assemblies of individual subunits arranged around a central, chloride-conducting pore. To date, 16 human GABA(A) receptor subunit genes have been characterized and grouped together according to their amino acid similarity and termed: α(1–6), β(1–3), δ(1–3), γ, ε, θ, and π1. Each subunit has a large extracellular N-terminal domain, four hydrophobic membrane-spanning domains that form the channel region and a small extracellular C-terminus. These subunits can combine in many different ways to form functional receptors, but most synaptic receptors contain two α subunits (α 1–3 isoforms), two β subunits, and a γ subunit arranged in the order γ-β-α-β-α3.nThe β1 subunit gene is located in the β1- α4- α2- γ1 gene cluster on chromosome , and is most highly expressed in the adult rat hippocampus. GABA(A) R genes are postulated to play a role in neuronal maturation, synaptogenesis, and predisposition to neurological disease. Increases in GABA levels and changes in GABA(A) R subunit gene expression, including decreased β1 mRNA levels, have been observed in animal models of epilepsy. Recent genetic studies have implicated GABA(A) β1 Receptor (GABRB1) in bipolar disorder, schizoaffective disorder and major depression. In addition, GABRB1 is associated with the risk of alcohol dependence

应用类型: 经验证，该抗体可应用于WB等实验应用，也可用于IC、IFC、IH、IP等实验。

免疫原: GABA(A) Beta1 受体抗体的免疫原肽段为(C)DQSANEKNKLEMNK。此免疫原序列来源于345-358 位氨基酸残基，该序列来源于大鼠(Accession编号为P15431)。第二胞内环。

来源宿主: 兔

反应性: 反应性：人、小鼠、大鼠

保存建议: 艾美捷为您提供的GABA(A) Beta1 受体抗体(25 ul)为室温运输，建议您收到产品后﹣20℃保存。

其他: Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。