胰高血糖素受体（胞外）抗体（25 ul）-Anti-Glucagon Receptor （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

PRODUCT CENTER

一抗

开云·官方站线上登录平台入口_开云(中国)

当前位置：开云·官方站线上登录平台入口 > 开云·官方站线上登录平台入口_开云(中国) > 免疫学产品 > 一抗

背景资料: The glucagon receptor (GCGR) is one of the 15 members of the secretin-like (class B) family of G-protein-coupled receptors (GPCRs) in humans. Glucagon is a highly conserved 29 amino acid protein processed from proglucagon by PC2 in pancreatic α-cells. The principal actions of glucagon involve regulation of metabolic pathways involved in glucose homeostasis1. Glucagon binding to the GCGR activates adenylyl cyclase through heterotrimeric Gs G proteins, leading to an increase in intracellular cAMP levels and subsequent activation of PKA signaling.nThe glucagon receptor is a 485-amino acid protein with a central core consisting of seven membrane-spanning domains, an extracellular N-terminus and a cytoplasmic C-terminal tail.Glucagon receptors are widely expressed in multiple tissues including the liver, brain, pancreas, heart, kidney, and smooth muscle cell in the gastrointestinal tract and peripheral vasculature.Abnormal glucagon signaling is associated with hyperglycemia in patients with type 2 diabetes. Mice with homozygous null mutation of GCGR exhibit chronic hypoglycemia, extreme hyperglucagonemia, and α cell hyperplasia4. GCGR is a potential drug target for type 2 diabetes.

免疫原: Glucagon 受体 (胞外)抗体的免疫原肽段为(C)KTRYSQKIGDDLS。此免疫原序列来源于200- 212 位氨基酸残基，该序列来源于大鼠Glucagon 受体 (Accession编号为P30082)。第二胞外环。

其他: Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。