GABA转运蛋白1（GAT-1）（胞外）抗体（50 ul）-Anti-GABA Transporter 1 （GAT-1) （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: γ-aminobutiric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Transmission via GABA can be halted by its reuptake through GABA transporters (GATs). These membrane proteins belong to the super family of slc6 genes which encode transporters responsible for the uptake of dopamine, serotonin, norepinephrine, glycine and GABA in a Na+-dependent manner.nTo date, four GATs have been identified: GAT-1, GAT-2, GAT-3 and BGT-1. Like all members of the slc6 family, they have twelve transmembrane domains and short intracellular N- and C-termini1. GATs couple the transport of one GABA molecule to 2Na+ ions and one Cl- ion3. GAT-1 activity can be regulated at the level of its plasma membrane expression which is in part regulated by its trafficking via phosphorylation of residues in intracellular loops.nGAT-1 expression is restricted to the central nervous system, specifically to axon terminals, in the neocortex and in some astrocytic processes.GAT-1 may be implicated in various psychological and neurological disorders such as schizophrenia, epilepsy and cerebral ischemia.

免疫原: GABA Transporter 1 (GAT-1) (胞外)抗体的免疫原肽段为(C)ERNMHQMTDGLDK。此免疫原序列来源于residues 194-206 位氨基酸残基，该序列来源于大鼠GABA Transporter 1 (Accession编号为P23978)。第二胞外环。

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