人BLT1（胞外）抗体（50 ul）-Anti-Human BLT1 （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Leukotrienes (LTs) are lipid mediators prominently exerting proinflammatory responses. They are divided in two classes: cysteinyl LTs (cysLTs) which have a thioester linkage and LTB4. LTB4, a chemoattractant plays a prominent role in the recruitment and activation of leukocytes.nLTB4 acts through two receptors which belong to the G-protein coupled receptor superfamily: BLT1 and BLT2. BLT1 displays high affinity for LTB4 and is highly expressed in leukocytes including granulocytes, macrophages, mast cells, dendritic cells and effector T cells and is expressed to much lower levels in spleen, thymus, heart, skeletal muscle brain and liver. BLT2 on the other hand is a low affinity receptor which does not display selectivity towards LTB45. Its expression is much more ubiquitous than that of BLT1. It is expressed in most human tissues, with the highest expression being in spleen, liver, ovary, and leukocytes. The two receptors could couple and activate different G-proteins, depending on the cell type and the cellular events activating the receptors. However, activation of BLT1 ususally correlates with increasing intracellular concentrations of Ca2+.

免疫原: Human BLT1 (胞外)抗体的免疫原肽段为CFPRYPSEGHRAFH。此免疫原序列来源于168-181位氨基酸残基，该序列来源于人类BLT1 (Accession编号为Q15722)第二胞外环。

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