烟碱型乙酰胆碱受体Beta4（胞外）抗体（50 ul）-Anti-Nicotinic Acetylcholine Receptor Beta4 （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Acetylcholine, released by cholinergic neurons, activates two groups of acetylcholine receptors (AChRs); muscarinic AChRs (mAChRs) which belong to the superfamily of G-protein coupled receptors (GPCRs) and nicotinic AChRs (nAChRs) which belong to the ligand-gated ion channel superfamily. nAChRs also respond to nicotine, hence their name.nTo date, 17 different but related subunits of nAChRs have been identified and cloned. They consist of α subunits (α1-10), which is responsible for the binding of ligands. In fact, this subunit includes a Cys-loop in the first extracellular domain that is required for agonist binding. The other subunits responsible for making up the active receptor are the β (β1-4), γ, δ and ε subunits. Structurally, all subunits have the following: a conserved large extracellular N-terminal domain, 3 conserved transmembrane domains, a variable cytoplasmic loop and a fourth transmembrane domain with a short extracellular C-terminal domain. An active nAChR is generally a heteropentamer (homopentamers also exist) of these various subunits organized around a central pore

免疫原: Nicotinic Acetylcholine 受体 Beta4 (胞外)抗体的免疫原肽段为CYEGVNILRIPAKR。此免疫原序列来源于95-108 位氨基酸残基，该序列来源于大鼠nAChRb4 (Accession编号为P12392)。胞外，N端。

保存建议: 艾美捷为您提供的Nicotinic Acetylcholine 受体 Beta4 (胞外)抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。

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