Glial-Derived Neurotrophic Factor (GDNF) is a member of the TGF-β superfamily. GDNF signals through a multi-component receptor system, composed of a RET protooncogene and one of the four α1-α4 receptors.nGDNF promotes survival of various neuronal cells, including motoneurons, Purkinje cells and sympathetic neurons. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Cells that express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes, and skeletal muscle cells
应用类型
经验证,该抗体可应用于WB等实验应用,也可用于IC、IH、IP等实验。
免疫原
proGDNF抗体的免疫原肽段为(C)PEDYPDQFDDVMD。此免疫原序列来源于54-66位氨基酸残基,该序列来源于人类GDNF (precursor) (Accession编号为P39905)。 Pro-结构域 of the GDNF蛋白。