MATE1抗体（25 ul）-Anti-MATE1代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: MATE1 (SLC47A1) and MATE2 (SLC47A2) are multidrug and toxin extrusion transporter 1 and 2 function as cationic pumps in the kidneys, liver, and intestine1. Both MATEs excrete molecules with a positive net-charge from renal tubular epithelial cells in the kidney (where they are co-expressed with organic anion- and cation-transporters; OATs and OCTs), and into the urine. In the liver, MATE1, but not MATE2, regulates the transportation of tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP) – again, by cation-powered pumps.Overexpression of MATE1 is helpful in the delivery of metal-based anti-cancer drugs, such as cisplatin and oxaliplatin, as it effectively accumulates platinum intracellularly. Furthermore, a rare increase in copy number of MATE1 in maize protects the plant from aluminum (Al) toxicity. On the other hand, inhibition of MATE1 may lead to potentially dangerous drug-drug interactions, due to damaged drug extrusion regulation

免疫原: MATE1抗体的免疫原肽段为(C)ESHGEIMMTDLEKK。此免疫原序列来源于496-509 位氨基酸残基，该序列来源于小鼠 MATE1 (Accession编号为Q8K0H1)。第五胞内环。

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