NHERF-1抗体（50 ul）-Anti-NHERF-1代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: The Na+/H+ exchanger regulatory factor (EBP-50 or NHERF-1) is a 55 kD cytoplasmic protein adaptor that recruits a wide variety of cellular proteins. Many of the interacting proteins do so through the two tandem PDZ domains (protein-binding domains conserved in the mammalian synaptic protein PSD-95/DlgA/ZO-1) and the C-terminal ERM (ezrin, radixin, moesin) binding region. NHERF-1 was first identified as an adaptor necessary for the function of the Na+/H+ exchanger isoform 3(NHE3) in renal apical cells.1 Since then it has been identified in cells of epithelial origin in several tissues such as gastrointestinal and lung. NHERF-1 has been shown to interact with a growing number of proteins including ion channels (ROMK, CFTR, P2Y1, TRPC4 and TRPC6), growth factor receptors (PDGFR), phospholipase C isoforms (PLCb1, PLCb2, PLCb3), non-receptor protein tyrosine kinases (YAP65) and several cytoskeletal proteins that link membrane proteins to the underlying actin cytoskeleton.

免疫原: NHERF-1抗体的免疫原肽段为(C)IQKENSREALVEPA, 对应于261-274 位氨基酸残基，该序列来源于大鼠NHERF-1 (Accession编号为Q9JJ19)。Between the PDZ2和the ERM binding 结构域s。

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