Shank3/ProSAP2 is one of three members of the Shank/ProSAP family of proteins which contain five conserved protein domains – an ankyrin repeat (ANK), a Src homology 3 (SH3), a PSD-95/Discs large/ZO-1 (PDZ), a proline-rich region containing homer- and cortactin-binding sites (Pro), and a sterile alpha motif (SAM)1. Shank proteins localize in the postsynaptic density (PSD) of excitatory synapses where they function as master scaffolding proteins by interacting directly or indirectly with various proteins, including major types of glutamate receptors – NMDARs, AMPARs, and mGluRs – via different domains. Shank3 plays important roles in the formation, maturation, and maintenance of synapses
应用类型
经验证,该抗体可应用于WB等实验应用,也可用于IC、IH、IP等实验。
免疫原
Shank3抗体的免疫原肽段为(C)EKLPGSLRKGIPRTK。此免疫原序列来源于841-855 位氨基酸残基,该序列来源于大鼠Shank3 (Accession编号为Q9JLU4)。胞内, between the PDZ和the SAM 结构域s。