NaV1.1-ATTO-594抗体（50 ul）-Anti-NaV1.1-ATTO-594代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Voltage-gated Na+ channels (Nav) are essential for the generation of action potentials and for cell excitability1. Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav a subunits have been cloned and named Nav1.1-Nav1.94-5. The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7) and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9)2-3. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1 subunit.Nav1.1 is a tetrodotoxin-sensitive channel and is broadly expressed in neurons

免疫原: NaV1.1-ATTO-594抗体的免疫原肽段为(C)TASEHSREPSAAGRLSD。此免疫原序列来源于465-481 位氨基酸残基，该序列来源于大鼠Nav1。1 (Accession编号为P04774)。胞内环位于结构域 I和II

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