proBDNF（野生型小鼠）（50 ug）-proBDNF (WT-mouse)代理/参数/厂家-生化试剂-开云·官方站线上登录平台入口

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生化试剂

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背景资料: BDNF is a neurotrophic factor produced by proteolytic cleavage of its precursor, proBDNF. The biologically relevant form of the protein was thought to be the mature form, BDNF, which has been shown to affect the development of motoneurons, modulate synaptic transmission and affect axonal branching, dendrite growth and synapse number. These actions are mediated via the binding of BDNF to TrkB. Different actions are mediated by the binding of BDNF to p75 such as neuronal process retraction and neuronal apoptosis. The precursor form was thought to be important for the correct folding, secretion and trafficking of the mature protein. A single-nucleotide polymorphism (Val66 to Met) in the pro-domain of the human BDNF gene impairs intracellular trafficking and regulated secretion of BDNFnin primary cortical neurons and neurosecretory cells but not in endothelial and vascular cells. This has been shown to affect memory and lead to abnormal hippocampal function in humans.

产品描述: proBrain-Derived Neutrotrophic Factor (WT-mouse), Recombinant, E. coli

产品形式: BDNF is a neurotrophic factor produced by proteolytic cleavage of its precursor, proBDNF. The biologically relevant form of the protein was thought to be the mature form, BDNF, which has been shown to affect the development of motoneurons, modulate synaptic transmission and affect axonal branching, dendrite growth and synapse number. These actions are mediated via the binding of BDNF to TrkB. Different actions are mediated by the binding of BDNF to p75 such as neuronal process retraction and neuronal apoptosis. The precursor form was thought to be important for the correct folding, secretion and trafficking of the mature protein. A single-nucleotide polymorphism (Val66 to Met) in the pro-domain of the human BDNF gene impairs intracellular trafficking and regulated secretion of BDNFnin primary cortical neurons and neurosecretory cells but not in endothelial and vascular cells. This has been shown to affect memory and lead to abnormal hippocampal function in humans.

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