Citalopram is an extremely potent inhibitor and highly selective bicyclic serotonin-reuptake inhibitor (SSRIs) with IC50 value of 275 nM. The SSRIs selectively potentiate 5-HT neurotransmission by inhibiting serotonin reuptake. Citalopram competes with serotonin and imipramine for a common binding site1. The high specificity results in minimal effects on other neurotransmitter receptors and uptake. Thus, citalopram shows fewer of the anticholinergic or adrenolytic side effects associated with other psychotropic agents and it has minimal cardiotoxic side effects. Citalopram is structurally unrelated to other antidepressants, but it contains the chemical features associated with reversal of drug resistance. Citalopram is used for the management of depression. Citalopram is also used for treating obsessive compulsive disorder (OCD), panic disorder, premenstrual dysphoric syndrome (PMDD), anxiety disorder, and posttraumatic stress disorder.
产品描述
A Blocker of KV2 Channels and an Inhibitor of 5-HT Uptake
产品形式
Citalopram is an extremely potent inhibitor and highly selective bicyclic serotonin-reuptake inhibitor (SSRIs) with IC50 value of 275 nM. The SSRIs selectively potentiate 5-HT neurotransmission by inhibiting serotonin reuptake. Citalopram competes with serotonin and imipramine for a common binding site1. The high specificity results in minimal effects on other neurotransmitter receptors and uptake. Thus, citalopram shows fewer of the anticholinergic or adrenolytic side effects associated with other psychotropic agents and it has minimal cardiotoxic side effects. Citalopram is structurally unrelated to other antidepressants, but it contains the chemical features associated with reversal of drug resistance. Citalopram is used for the management of depression. Citalopram is also used for treating obsessive compulsive disorder (OCD), panic disorder, premenstrual dysphoric syndrome (PMDD), anxiety disorder, and posttraumatic stress disorder.