中文名称

环丙嗪（100毫克）

英文名字

Cyclothiazide

供应商

Alomone

产品货号

ALO-C-205-100

产品报价

￥已停产

产品说明书

购买方式

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产品新闻

背景资料

Cyclothiazide (CTZ) is one of the most potent benzothiadiazides, a class of positive allosteric modulators of non-NMDA-type glutamate receptors that inhibit receptor desensitization with a marked selectivity for the flip splice variants of AMPA receptors. Specifically, CTZ is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. By using patch-clamp techniques, the effects of CTZ were studied in HEK 293 cells stably transfected with the rat flip GluR1 subunit. The AMPA currents were greatly potentiated by CTZ in a dose-dependent manner. For instance, pretreatment of the cells with 100 μM CTZ increased the peak AMPA currents by 90-fold (EC50 = 28 μM), the currents at the end of AMPA application by 636-fold (EC50 = 46 μM), and the current integrals by 730-fold (EC50 = 41 μM).

产品描述

A Positive Allosteric Modulator of AMPA Receptors

产品形式

Cyclothiazide (CTZ) is one of the most potent benzothiadiazides, a class of positive allosteric modulators of non-NMDA-type glutamate receptors that inhibit receptor desensitization with a marked selectivity for the flip splice variants of AMPA receptors. Specifically, CTZ is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. By using patch-clamp techniques, the effects of CTZ were studied in HEK 293 cells stably transfected with the rat flip GluR1 subunit. The AMPA currents were greatly potentiated by CTZ in a dose-dependent manner. For instance, pretreatment of the cells with 100 μM CTZ increased the peak AMPA currents by 90-fold (EC50 = 28 μM), the currents at the end of AMPA application by 636-fold (EC50 = 46 μM), and the current integrals by 730-fold (EC50 = 41 μM).

保存建议

艾美捷为您提供的Alonmone Labs原装进口的Cyclothiazide (100 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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