钙西汀（70 ug）-Calciseptine代理/参数/厂家-生化试剂-开云·官方站线上登录平台入口

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生化试剂

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背景资料: Calciseptine is a natural peptide isolated from the Dendroaspis p. polylepsis black mamba venom, by a modification to the procedure of Schweitz et al. and purified to homogenity. Calciseptine was shown to be a specific L-type Cav channel blocker. In contrast, it increases L-type currents in skeletal muscle.Calciseptine blocks spontaneous or K+-induced contraction of cardiac and smooth muscle cells. Using patch clamp, it was also shown to block specifically L-type Cav channel current in neuronal cells in culture. For these variety of effects, the IC50's were in the range of 15-500 nM. Using the outside-out configuration of patch clamp, it was shown to reduce single L-type channels open probability and availability as recorded from Guinea pig portal vein.

产品形式: Calciseptine is a natural peptide isolated from the Dendroaspis p. polylepsis black mamba venom, by a modification to the procedure of Schweitz et al. and purified to homogenity. Calciseptine was shown to be a specific L-type Cav channel blocker. In contrast, it increases L-type currents in skeletal muscle.Calciseptine blocks spontaneous or K+-induced contraction of cardiac and smooth muscle cells. Using patch clamp, it was also shown to block specifically L-type Cav channel current in neuronal cells in culture. For these variety of effects, the IC50's were in the range of 15-500 nM. Using the outside-out configuration of patch clamp, it was shown to reduce single L-type channels open probability and availability as recorded from Guinea pig portal vein.

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