α-MSH is a neuropeptide originally isolated from the pituitary gland. α-MSH is produced by post-translational processing of a precursor protein, proopiomelanocortin (POMC). In most vertebrates but not in mammals, α-MSH is produced in the intermediate lobe of the pituitary gland. The biological activities of α-MSH are mediated through a family of five specific G-protein coupled receptors: MCR1, MCR2, MCR3, MCR4, and MCR5. α-MSH is an evolutionarily highly conserved peptide action that induces pigment dispersion in skin melanocytes of amphibians, reptiles and mammals by stimulating melanin production.
产品描述
A Ligand of Melanocortin G-Protein Coupled Receptor
产品形式
α-MSH is a neuropeptide originally isolated from the pituitary gland. α-MSH is produced by post-translational processing of a precursor protein, proopiomelanocortin (POMC). In most vertebrates but not in mammals, α-MSH is produced in the intermediate lobe of the pituitary gland. The biological activities of α-MSH are mediated through a family of five specific G-protein coupled receptors: MCR1, MCR2, MCR3, MCR4, and MCR5. α-MSH is an evolutionarily highly conserved peptide action that induces pigment dispersion in skin melanocytes of amphibians, reptiles and mammals by stimulating melanin production.