Charybdotoxin was originally isolated from the venom of the Israeli scorpion Leiurus quinquestriatus hebraeus. Charybdotoxin blocks KCa1.1 (large conductance Ca2+ activated K+, Slo) channels in nM concentrations as well as KV1.2 (Kd, 14 nM) and KV1.3 (Kd, 2.6 nM) channels. However, experiments with cloned KCa1.1 channels demonstrate the strong effect of the sloβ subunits on the potency of block by Charybdotoxin (see for example).
产品描述
A Blocker of KV1.2, KV1.3 and KCa1.1 K+ Channels
产品形式
Charybdotoxin was originally isolated from the venom of the Israeli scorpion Leiurus quinquestriatus hebraeus. Charybdotoxin blocks KCa1.1 (large conductance Ca2+ activated K+, Slo) channels in nM concentrations as well as KV1.2 (Kd, 14 nM) and KV1.3 (Kd, 2.6 nM) channels. However, experiments with cloned KCa1.1 channels demonstrate the strong effect of the sloβ subunits on the potency of block by Charybdotoxin (see for example).