Mu-芋螺毒素CnIIIC（1毫克）-Mu-Conotoxin CnIIIC代理/参数/厂家-生化试剂-开云·官方站线上登录平台入口

PRODUCT CENTER

生化试剂

开云·官方站线上登录平台入口_开云(中国)

当前位置：开云·官方站线上登录平台入口 > 开云·官方站线上登录平台入口_开云(中国) > 分子生化产品 > 生化试剂

背景资料: µ-Conotoxin CnIIIC, a 22-residue conopeptide from Conus consors belonging to µ-conopeptide family, is a very potent, selective and durable antagonist of NaV channels. This toxin blocks both voltage-gated Na+ channels and neuronal nicotinic acetylcholine receptor (nAChR). µ-Conotoxin CnIIIC inhibits the rat skeletal muscle NaV1.4 with IC50 of 1.3 nM and the rat brain NaV1.2 expressed in HEK-293 cells. A low inhibition is also observed for mouse neuronal NaV1.6 and mouse NaV1.7. µ-Conotoxin CnIIIC modestly blocks nAChR α3/β2 subtype with IC50 values of 450 nM (partially reversible) and, to a lesser extent, α7 and α4/β2 subtypes (reversible) expressed in Xenopus oocytes. in vitro, it decreases twitch tension in mouse hemidiaphragms (IC50 = 150 nM) and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50 = 46 nM).

产品形式: µ-Conotoxin CnIIIC, a 22-residue conopeptide from Conus consors belonging to µ-conopeptide family, is a very potent, selective and durable antagonist of NaV channels. This toxin blocks both voltage-gated Na+ channels and neuronal nicotinic acetylcholine receptor (nAChR). µ-Conotoxin CnIIIC inhibits the rat skeletal muscle NaV1.4 with IC50 of 1.3 nM and the rat brain NaV1.2 expressed in HEK-293 cells. A low inhibition is also observed for mouse neuronal NaV1.6 and mouse NaV1.7. µ-Conotoxin CnIIIC modestly blocks nAChR α3/β2 subtype with IC50 values of 450 nM (partially reversible) and, to a lesser extent, α7 and α4/β2 subtypes (reversible) expressed in Xenopus oocytes. in vitro, it decreases twitch tension in mouse hemidiaphragms (IC50 = 150 nM) and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50 = 46 nM).

保存建议: 艾美捷为您提供的Alonmone Labs原装进口的Mu-Conotoxin CnIIIC (1 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他: Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。