β-theraphotoxin-Gr1a (GrTx1) is a peptidyl toxin originally isolated from the venom of the ‘‘rosean-tarantula’’ (Grammostola rosea). GrTx1 has 29 amino-acid residues, compactly folded by three disulfide bridges with a molecular weight of 3697 Da. Sequence analysis reveals that GrTx1 is closely related to other spider toxins reported to affect various distinct ion channel functions. The toxin inhibits NaV1.1 (IC50 = 0.63 μM), NaV1.2 (IC 50= 0.23 μM), NaV1.3 (IC 50 = 0.77 μM), NaV1.4 (IC 50= 1.29 μM), NaV1.6 (IC 50= 0.63 μM), NaV1.7 (IC 50= 0.37 μM) and potassium channels KV11.1 (IC 50 = 1.2 μM).
产品描述
A Blocker of NaV and KV11.1 Channels
产品形式
β-theraphotoxin-Gr1a (GrTx1) is a peptidyl toxin originally isolated from the venom of the ‘‘rosean-tarantula’’ (Grammostola rosea). GrTx1 has 29 amino-acid residues, compactly folded by three disulfide bridges with a molecular weight of 3697 Da. Sequence analysis reveals that GrTx1 is closely related to other spider toxins reported to affect various distinct ion channel functions. The toxin inhibits NaV1.1 (IC50 = 0.63 μM), NaV1.2 (IC 50= 0.23 μM), NaV1.3 (IC 50 = 0.77 μM), NaV1.4 (IC 50= 1.29 μM), NaV1.6 (IC 50= 0.63 μM), NaV1.7 (IC 50= 0.37 μM) and potassium channels KV11.1 (IC 50 = 1.2 μM).
保存建议
艾美捷为您提供的Alonmone Labs原装进口的GrTx1 (5 x 50 µg)产品可室温运输,建议您在收到产品后将其置于合适的温度下保存。