中文名称

Thapsigargin（1毫克）

英文名字

Thapsigargin

供应商

Alomone

产品货号

ALO-T-650-1

产品报价

￥已停产

产品说明书

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

Thapsigargin, derived from the plant genus Thapsia, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent which induces rapid Ca2+ release from intracellular stores by inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-dependent ATPase pump without inositol phosphate formation.The thapsigargin induced depletion of Ca2+ stores causes apoptosis in most cell lines. It has also been shown to cause histamine secretion from rat mast cells, and to stimulate arachidonic acid metabolism in macrophages. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in skin. The tumorogenic activity of thapsigargin might be due to its activation of protein kinase B (Akt) which subsequently stimulates MAP kinase signaling via Src and Raf-3.

产品描述

An Intracellular Ca2+ Immobilizer

产品形式

Thapsigargin, derived from the plant genus Thapsia, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent which induces rapid Ca2+ release from intracellular stores by inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-dependent ATPase pump without inositol phosphate formation.The thapsigargin induced depletion of Ca2+ stores causes apoptosis in most cell lines. It has also been shown to cause histamine secretion from rat mast cells, and to stimulate arachidonic acid metabolism in macrophages. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in skin. The tumorogenic activity of thapsigargin might be due to its activation of protein kinase B (Akt) which subsequently stimulates MAP kinase signaling via Src and Raf-3.

保存建议

艾美捷为您提供的Alonmone Labs原装进口的Thapsigargin (1 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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