【KIR2DL1】小鼠抗人杀伤细胞免疫球蛋白样受体2DL1抗体-Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor， 2 Domains Long Cytoplasmic Tail 1代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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英文名字: Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor， 2 Domains Long Cytoplasmic Tail 1

背景资料: Killer-cell immunoglobulin-like receptors （KIRs）， are a family of cell surface glycoproteins found on Natural Killer （NK） Cells， which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules， which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory， which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex （LRC）. KIR molecules are extremely polymorphic， meaning their gene sequences differ significantly between individuals， so that different individuals have different arrays/repertoires of KIR genes. The KIR proteins are categorized by the number of

免疫原: Anti-human KIR2DL1 mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KIR2DL1 amino acids 23-223 purified from E. coli.

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