2-Probe bone affinity sampler(AF647-RIS (24 nmol) + 56-FAM-RISPC (24 nmol)),2-Probe bone affinity sampler(AF647-RIS (24 nmol) + 56-FAM-RISPC (24 nmol))
产品描述
2-Probe bone affinity sampler(AF647-RIS (24 nmol) + 56-FAM-RISPC (24 nmol)),This sampler kit includes two imaging probes with different spectroscopic properties as well as variable bone affinities (AF647-RIS has stronger affinity than 5(6)-FAM-RISPC). The probes are fluorescent conjugates of risedronate, a widely used bisphosphonate drug in clinical applications, and its phosphonocarboxylate analogue. There is also an option of adding the calcein (a fluorescent molecule with even lower bone affinity) in the kit. The kit can be used for simultaneous detection with co-dosing and studies on effects of bone affinity, and is a great, economical complement to the 3-probe bone affinity kit.n nSpectroscopic properties of AF647-RIS:nMaximum absorption wavelength (λmax (abs)): 648 nmnMaximum emission wavelength (λmax (em)): 666 nmnExtinction coefficient (M-1cm-1): 240,000 (0.1 M phosphate buffer, pH 7.0)n nSpectroscopic properties of 5(6)-FAM-RISPC:nMaximum absorption wavelength (λmax (abs)): 493 nmnMaximum emission wavelength (λmax (em)): 518 nmnExtinction coefficient (M-1cm-1): 73,000 (0.1 M phosphate buffer, pH 7.2)