Recombinant Human Peptidyl-Prolyl Cis/Trans Isomerase NIMA-Interacting 1
供应商
ProSpec
产品货号
ENZ-331
产品报价
¥询价/1mg ¥20ug ¥5ug
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产品新闻
背景资料
Human Pin 1 is a peptidyl-prolyl cis/trans isomerase(PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators(Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like b-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.