Recombinant Human Ubiquitin-Conjugating Enzyme E2K
供应商
ProSpec
产品货号
ENZ-339
产品报价
¥询价/10ug ¥1mg ¥2ug
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产品新闻
背景资料
Among ubiquitin-conjugating enzymes, the mammalian ubiquitin conjugating enzyme UbcH1, also known as HIP2, is unique in its ability to catalyze the in vitro synthesis of unanchored Lys48-linked poly-ubiquitin chains from mono- or poly-ubiquitin, E1, and ATP. In addition, UbcH1 can catalyse the cyclization of longer poly-ubiquitin chains, including tetra- and penta-ubiquitin. Recombinant UbcH1 charges and supports ubiquitinylation in vitro. Typical enzyme concentration to support conjugation in vitro is 100nM to 1?M. Recently, HIP2(or UbcH1) has been shown to bind to the N terminus of Huntington and may play a role in Huntington disease.