Recombinant Human Aldo-Keto Reductase Family 1 Member C3, His Tag
供应商
ProSpec
产品货号
ENZ-406
产品报价
¥询价/1mg ¥20ug ¥5ug
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产品新闻
背景资料
AKR1C3 is part of the aldo/keto reductase superfamily, which has at least 40 identified proteins. AKR1C3 catalyzes the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. AKR1C3 displays overlapping but distinct substrate specificity. AKR1C3 catalyzes the reduction of prostaglandin(PG) D2, PGH2 and phenanthrenequinone(PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. AKR1C3 is involved in the pathogenesis of allergic diseases such as asthma. AKR1C3 controls cell growth and/or differentiation. AKR1C3, having ability to convert androstenedione to testosterone, itakes part in adrenal testosterone production. AKR1C3 expression is affected by metabolic disease, and its levels are considerably reduced in response to diet-induced weight loss and correlate with leptin levels.