【PAPP-A】重组妊娠相关血浆蛋白1-Recombinant Human Pregnancy-Associated Plasma Protein-1代理/参数/厂家-酶-开云·官方站线上登录平台入口

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背景资料: PAPPA is a large zinc binding protein， which acts as a metalloprotease and specifically cleaves IGFBP-4 and IGFBP-5， resulting in release of bound IGF. PAPP-A can also act as a regulator of IGF bioactivity in a number of biological systems， including the human ovary and cardiovascular systems. It was shown that PAPP A levels are elevated in patients with unstable angina or acute myocardial infarction. Furthermore， PAPPA is believed to be involved in local proliferative processes such as wound healing and bone remodeling. Moreover， PAPP-A is produced in high concentrations during pregnancy and is released into the maternal circulation. In placenta， PAPP A is expressed in X cells in septa and anchoring villi， and in syncytiotrophoblasts in the chorionic villi.
Lower levels of PAPPA are found in an array of other tissues including kidney， myometrium， endometrium， ovaries， breast， prostate， bone marrow， colon， fibroblasts and osteoblasts. PAPP-A is present in serum and placenta during pregnancy； with levels increasing throughout pregnancy. Low levels of PAPP A are associated with a number of foetal chromosomal abnormalities， as well as pre-eclampsia and stillbirth.
PAPPA levels may be a potentially highly specific marker for heart disease.
PAPP-A proteolytic activity is inhibited by targeting substrate exosite binding.

溶解建议: 提供的妊娠相关血浆蛋白1（PAPP-A）产品为过滤灭菌的透明溶液；其中妊娠相关血浆蛋白1（PAPP-A）产品溶解于1x PBS，50%甘油溶液中.

其他: ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。